کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6278074 1295793 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intrinsic versus extrinsic determinants during the development of Purkinje cell dendrites
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Intrinsic versus extrinsic determinants during the development of Purkinje cell dendrites
چکیده انگلیسی
Different culture models and mutant mice analyses suggest the identification of intrinsic versus extrinsic determinants of the Purkinje cell dendritic development. The early phase of dendritic remodeling might be cell autonomous and regulated by specific transcription factors such as retinoid-related orphan receptor alpha (RORα). Afferent fibers, trophic factors and hormones regulate the orientation and growth of the mature dendritic tree contributing, with still unknown intrinsic factors, to sculpt its general architecture. The formation of spines appears as an intrinsic phenomenon independent of their presynaptic partner, the parallel fibers, and confined to the distal compartment by inhibitory influences of the climbing fibers along the proximal compartment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 162, Issue 3, 1 September 2009, Pages 589-600
نویسندگان
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