Review articleProspects for genetically modified non-human primate models, including the common marmoset

- The demands of non-human primate (NHP) laboratory animals in biomedical science are increasing.
- Recently, several NHPs models have been produces using genetically modified techniques.
- Genome editing techniques would be expected technologies for new model NHPs production by target gene knockout.

Genetically modified mice have contributed much to studies in the life sciences. In some research fields, however, mouse models are insufficient for analyzing the molecular mechanisms of pathology or as disease models. Often, genetically modified non-human primate (NHP) models are desired, as they are more similar to human physiology, morphology, and anatomy. Recent progress in studies of the reproductive biology in NHPs has enabled the introduction of exogenous genes into NHP genomes or the alteration of endogenous NHP genes. This review summarizes recent progress in the production of genetically modified NHPs, including the common marmoset, and future perspectives for realizing genetically modified NHP models for use in life sciences research.