C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury

Morphological changes of myelin and axons showed similar degeneration and regeneration patterns in WT and C6−/− injured nerves. Functional degeneration and regeneration, recorded by ex vivo electrophysiology and in vivo foot flick test, showed that the timeline of the restoration of nerve conduction and sensory recovery also followed similar patterns in WT and C6−/− animals. Our findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury.