کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6286234 1615299 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid CommunicationIntrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats
ترجمه فارسی عنوان
ارتباطات سریع ارتباط تزریق داخلپیپوتالامام کانابیدیول سطوح خارج سلولی آدنوزین را در هسته تکامن در موش صحرایی افزایش میدهد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Cannabidiol promotes adenosine accumulation.
- Microinjection of cannabidiol increases extracellular levels of adenosine.
- Cannabidiol enhances sleep-inducing molecule.

Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10 μg/1 μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2 h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 84, July 2014, Pages 60-63
نویسندگان
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