کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6286329 | 1615303 | 2014 | 9 صفحه PDF | دانلود رایگان |
- Adaptation of cortical LFPs to a tone sequence was investigated.
- Amplitude adaptation occurred within a second.
- Phase adaptation persists over multiple seconds.
- Phase adaptation was effective in slower oscillation in contrast to amplitude.
Sensory adaptation allows stimulus sensitivity to be dynamically modulated according to stimulus statistics and plays pivotal roles in efficient neural computation. Here, it is hypothesized that in the auditory cortex, phase locking of local field potentials (LFPs) to test tones exhibits an adaptation property, i.e., phase-locking adaptation, which is distinct from the amplitude adaptation of oscillatory components. Series of alternating tone sequences were applied in which the inter-tone interval (ITI) and frequency difference (ÎF) between successive tones were varied. Then, adaptation was characterized by the temporal evolution of the band-specific amplitude and phase locking evoked by the test tones. Differences as well as similarities were revealed between amplitude and phase-locking adaptations. First, both amplitude and phase-locking adaptations were enhanced by short ITIs and small ÎFs. Second, the amplitude adaptation was more effective in a higher frequency band, while the phase-locking adaptation was more effective in a lower frequency band. Third, as with the adaptation of multiunit activities (MUAs), the amplitude adaptation occurred mainly within a second, while the phase-locking showed multi-second adaptation specifically in the gamma band for short ITI and small ÎF conditions. Fourth, the amplitude adaptation and phase-locking adaptation were co-modulated in a within-second time scale, while this co-modulation was not observed in a multi-second time scale. These findings suggest that the amplitude and phase-locking adaptations have different mechanisms and functions. The phase-locking adaptation is likely to play more crucial roles in encoding a temporal structure of stimulus than the amplitude adaptation.
Journal: Neuroscience Research - Volume 79, February 2014, Pages 52-60