Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke

► Notch signaling is activated in NG2+ glial progenitors and reactive astrocytes. ► DAPT reduced the proliferation of reactive astrocytes but not NG2+ glial progenitors. ► DAPT inhibited nuclear-translocation of Olig2 in reactive astrocytes in vivo.