کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6286670 1299014 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cellular and molecular landscape of neuroligins
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The cellular and molecular landscape of neuroligins
چکیده انگلیسی
A fundamental physical interaction exists across the synapse. It is mediated by synaptic adhesion molecules, and is among the earliest and most indispensable of molecular events occurring during synaptogenesis. The regulation of adhesion molecules and their interactions with other synaptic proteins likely affect not only on synapse formation but also on ongoing synaptic function. We review research on one major family of postsynaptic adhesion molecules, neuroligins, which bind to their presynaptic partner neurexin across the synaptic cleft. We move from a structural overview to the broad cellular and synaptic context of neuroligins, intermolecular interactions, and molecular modifications that occur within a synapse. Finally, we examine evidence concerning the physiological functions of neuroligin in a cell and highlight areas requiring further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Neurosciences - Volume 38, Issue 8, August 2015, Pages 496-505
نویسندگان
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