Effective reduction of Vibrio vulnificus in the Eastern oyster (Crassostrea virginica) using high salinity depuration

► Reduction of Vibrio vulnificus numbers in oysters was accomplished by depuration. ► High salinities of 25 and 35 psu were more efficient than 15 psu. ► Only 35 psu was able to eliminate this pathogen to non-detectable levels. ► Oyster mortality was very low but condition index decreased during depuration.