کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6368730 1623656 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo pretreatment of Eudrilus eugeniae powder attenuates β-adrenoceptor toxicity mediated by isoproterenol in rat model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
In vivo pretreatment of Eudrilus eugeniae powder attenuates β-adrenoceptor toxicity mediated by isoproterenol in rat model
چکیده انگلیسی
The present study was designed to discover the potential cardioprotective function of earthworm powder (EWP) extracted from Eudrilus eugeniae on isoproterenol (ISO)-induced myocardial infarction in male Wistar rats. The rats were divided into four groups, with six rats in each group. Certain rats were pretreated with EWP (200 mg/kg bwt) (Group III), and a myocardial infarction was then induced by subcutaneous injection of ISO (85 mg/kg bwt) (Group II). Oral pretreatment of 200 mg/kg bwt of EWP for 28 days significantly (p > 0.05) improved the blood profile levels, including (a) the lipid profile of total cholesterol (TC), free fatty acids (FFA), and triglycerides (TG); (b) low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), and protein; and (c) A/G ratio, glucose and uric acid levels. The electrophoretic pattern of elevated lactose dehydrogenase (LDH) levels was recovered by EWP treatment as evidenced by comparison with ISO-induced rats with cardiac damage. The above results indicate that EWP (200 mg/kg bwt) provides a cardioprotective effect by attenuating the blood profile, lipid profile, biochemical levels, and LDH patterns in rats that experienced an ISO-induced myocardial infarction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Basic & Applied Zoology - Volume 76, August 2016, Pages 1-6
نویسندگان
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