کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6369005 | 1623806 | 2016 | 11 صفحه PDF | دانلود رایگان |
- Mathematical models are constructed to investigate the phenomenon of 'cell competition' where one group of normal cells in epithelial tissues competes with another group of mutant cells through an interaction at their interface.
- The models can reproduce several typical experimental observations.
- An index of group fitness is proposed to predict the outcome of the competition between the two groups.
The phenomenon of 'cell competition' has been implicated in the normal development and maintenance of organs, such as in the regulation of organ size and suppression of neoplastic development. In cell competition, one group of cells competes with another group through an interaction at their interface. Which cell group “wins” is governed by a certain relative fitness within the cells. However, this idea of cellular fitness has not been clearly defined. We construct two types of mathematical models to describe this phenomenon of cell competition by considering the interaction at the interface as a predator-prey type interaction in a monolayer tissue such as epithelium. Both of these models can reproduce several typical experimental observations involving systems of mutant cells (losers) and normal cells (winners). By analyzing one of the model and defining an index for the degree of fitness in groups of cells, we show that the fate of each group mainly depends on the relative carrying capacities of certain resources and the strength of the predator-prey interaction at the interface. This contradicts the classical hypothesis in which the relative proliferation rate determines the winner.
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Journal: Journal of Theoretical Biology - Volume 404, 7 September 2016, Pages 40-50