کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6369324 1623820 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mathematical model of cell equilibrium and joint cell formation in multiple myeloma
ترجمه فارسی عنوان
یک مدل ریاضی تعادل سلولی و تشکیل سلول مشترک در مولتیپل میلوما
کلمات کلیدی
میلوما چندگانه، سیتوکین های پاراکرین، سلولهای مینیمم / استئوکلست، مدل سازی ریاضی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
In Multiple Myeloma Bone Disease healthy bone remodelling is affected by tumour cells by means of paracrine cytokinetic signalling in such a way that osteoclast formation is enhanced and the growth of osteoblast cells inhibited. The participating cytokines are described in the literature. Osteoclast-induced myeloma cell growth is also reported. Based on existing mathematical models for healthy bone remodelling a three-way equilibrium model is presented for osteoclasts, osteoblasts and myeloma cell populations to describe the progress of the illness in a scenario in which there is a secular increase in the cytokinetic interactive effectiveness of paracrine processes. The equilibrium state for the system is obtained. The paracrine interactive effectiveness is explored by parameter variation and the stable region in the parameter space is identified. Then recently-discovered joint myeloma-osteoclast cells are added to the model to describe the populations inside lytic lesions. It transpires that their presence expands the available parameter space for stable equilibrium, thus permitting a detrimental, larger population of osteoclasts and myeloma cells. A possible relapse mechanism for the illness is explored by letting joint cells dissociate. The mathematics then permits the evaluation of the evolution of the cell populations as a function of time during relapse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 390, 7 February 2016, Pages 73-79
نویسندگان
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