کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6370317 | 1623851 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The fuzzy oil drop model, based on hydrophobicity density distribution, generalizes the influence of water environment on protein structure and function
ترجمه فارسی عنوان
مدل قطره روغن فازی که براساس توزیع تراکم هیدروفوبیتی است، تأثیر محیط آب بر روی ساختار و عملکرد پروتئین را تعمیم می دهد
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کلمات کلیدی
محیط آب، هسته هیدروفوب آمیلوئیدوز، تانستتیین، ایمونوگلوبولین مانند شکل،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
In this paper we show that the fuzzy oil drop model represents a general framework for describing the generation of hydrophobic cores in proteins and thus provides insight into the influence of the water environment upon protein structure and stability. The model has been successfully applied in the study of a wide range of proteins, however this paper focuses specifically on domains representing immunoglobulin-like folds. Here we provide evidence that immunoglobulin-like domains, despite being structurally similar, differ with respect to their participation in the generation of hydrophobic core. It is shown that β-structural fragments in β-barrels participate in hydrophobic core formation in a highly differentiated manner. Quantitatively measured participation in core formation helps explain the variable stability of proteins and is shown to be related to their biological properties. This also includes the known tendency of immunoglobulin domains to form amyloids, as shown using transthyretin to reveal the clear relation between amyloidogenic properties and structural characteristics based on the fuzzy oil drop model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 359, 21 October 2014, Pages 6-17
Journal: Journal of Theoretical Biology - Volume 359, 21 October 2014, Pages 6-17
نویسندگان
Mateusz Banach, Leszek Konieczny, Irena Roterman,