کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6370692 | 1623875 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The breakdown of the word symmetry in the human genome
ترجمه فارسی عنوان
فروپاشی تقارن کلمه در ژنوم انسان
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کلمات کلیدی
تقارن یک رشته، ترکیب اولیگونوکلئوتید، فاصله تقریبی کلمه، آزمون انعطاف پذیری،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Previous studies have suggested that Chargaff's second rule may hold for relatively long words (above 10Â nucleotides), but this has not been conclusively shown. In particular, the following questions remain open: Is the phenomenon of symmetry statistically significant? If so, what is the word length above which significance is lost? Can deviations in symmetry due to the finite size of the data be identified? This work addresses these questions by studying word symmetries in the human genome, chromosomes and transcriptome. To rule out finite-length effects, the results are compared with those obtained from random control sequences built to satisfy Chargaff's second parity rule. We use several techniques to evaluate the phenomenon of symmetry, including Pearson's correlation coefficient, total variational distance, a novel word symmetry distance, as well as traditional and equivalence statistical tests. We conclude that word symmetries are statistical significant in the human genome for word lengths up to 6Â nucleotides. For longer words, we present evidence that the phenomenon may not be as prevalent as previously thought.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 335, 21 October 2013, Pages 153-159
Journal: Journal of Theoretical Biology - Volume 335, 21 October 2013, Pages 153-159
نویسندگان
Vera Afreixo, Carlos A.C. Bastos, Sara P. Garcia, João M.O.S. Rodrigues, Armando J. Pinho, Paulo J.S.G. Ferreira,