Modeling the influence of nucleus elasticity on cell invasion in fiber networks and microchannels

► Cellular Potts model. ► Effect of nucleus elasticity and pore size on cell migration in microchannels and ECM. ► Cytoskeletal and nuclear elasticity correlate with the invasive potential of cells. ► Biphasic dependence on pore size as in experiments. ► Two migration modes (oscillatory and steady) as observed in the literature.