A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

► We use a spatial cell-based model to study monoclonal conversion in the crypt. ► Mutations are introduced with varied height, proliferation and adhesion. ► Mutations occurring more than one cell from the crypt base rarely dominate. ► Changes to adhesion can significantly affect probability of domination. ► Changes to proliferation cause non-linear changes to the probability of domination.