A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies

► DNA methylation is perturbed in myelodysplasia and leukemia. ► We model DNA methylation using a dynamic multicompartmental approach. ► Levels of methylation depend on enzymatic activity of Dnmt and Tet family proteins. ► Predicted methylation levels are consistent with published experimental data. ► Increased Tet activity maintains hypomethylation at CpG islands.