Modelling the anabolic response of bone using a cell population model

► Precursor osteoblasts proliferation is a potent mechanism for anabolic response. ► Osteoblast differentiation and proliferation concur for proper bone formation control. ► Action of Wnt and pth in bone remodelling may explain a variety of bone responses. ► Wnt/Dkk1 production by prostate cancer can drive the type of metastatic bone lesions.