Modelling the interactions between TLR4 and IFNβ pathways

► TLR4 and IFNβ pathways interaction mechanism is investigated by a mathematical model. ► The nonlinear character of transcription is modeled by statistical physics techniques. ► PKR late phase is pinpointed in the realm of interacting pathways dynamics. ► Empirical IRF3, IFNβ and PKR data are recapitulated in physiological feasible limits. ► The nonlinear system dose-response profiles are proposed through model details.