The effects of a telomere destabilizing agent on cancer cell-cycle dynamics-Integrated modelling and experiments

► We mathematically model cell-cycle dynamics using a system of coupled ODEs. ► We report results of original experiments on HCT116 cells. ► We investigate the effects of a DNA interactive agent (RHPS4) by parameter fitting. ► RHPS4 affects cancer cells in the G2/M phase of the cell cycle. ► The drug causes delayed cell death which is dose-dependent.