کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6371466 | 1623926 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pathway knockout and redundancy in metabolic networks
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
Additionally, we compare existing enzyme knockout and our pathway knockout algorithm by the mean-field analysis, which provides mathematical expression for the average ratio of remaining EFMs after both types of knockout. Our results prove that multiple-enzymes knockout does not always yield more information than single-enzyme knockout for evaluating redundancy. Indeed, pathway knockout considers additional effects of structural asymmetry. In the metabolic networks of amino acid anabolism in Escherichia coli and human hepatocytes, and the central metabolism in human erythrocytes, we validate our mean-field solutions and prove the capacity of pathway knockout algorithm. Moreover, in the E. coli model the two sub-networks synthesizing amino acids that are essential and those that are non-essential for humans are studied separately. In contrast to previous studies, we find that redundancy of two sub-networks is similar with each other, and even sub-networks synthesizing essential amino acids can be more redundant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 270, Issue 1, 7 February 2011, Pages 63-69
Journal: Journal of Theoretical Biology - Volume 270, Issue 1, 7 February 2011, Pages 63-69
نویسندگان
Yong Min, Xiaogang Jin, Ming Chen, Zhengzheng Pan, Ying Ge, Jie Chang,