Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure

► Cloning and characterization of 3 isoforms of GPx1 and GPx4 gene in rainbow trout. ► GPx1 and GPx4 genes constitutive expression in 18 trout tissues. ► GPx1 and GPx4 genes modulation by inorganic and organic selenium in vitro. ► Comparison of gene expression, enzymatic activity and cell viability. ► Sensitive biomarkers in rainbow trout for selenium exposure.