Dose- and time-related changes in aerobic metabolism, chorionic disruption, and oxidative stress in embryonic medaka (Oryzias latipes): Underlying mechanisms for silver nanoparticle developmental toxicity

► Silver nanoparticles (AgNPs) were self-synthesized, purified, and well characterised. ► AgNPs induced a number of morphological changes and affected the fish eggs ability to keep osmotic balance. ► Homeostasis related to oxidative stress was impaired, and some biomarkers exhibited dose- and time-dependent changes. ► Well-developed pre-hatching medaka is more resistant to AgNP exposure.