Catalytic CO2 hydration by immobilized and free human carbonic anhydrase II in a laminar flow microreactor - Model and simulations

► CO2 hydration catalyzed by HCA II enzyme in a laminar flow microreactor. ► Hydrodynamic-diffusion limitations do not allow reasonable use of immobilized HCA. ► Uncatalyzed bulk CO2 hydration is dominant in microreactor with immobilized HCA. ► Plug flow is achieved in laminar flow microreactor with solution-phase HCA enzyme. ► Uncatalyzed CO2 hydration process is not considerable with solution-phase HCA.