Separation of yeast from alcoholic fermentation in small hydrocyclones

► The separation process of yeast from fermentation using hydrocyclones was accomplished. ► The effect of different geometric variables and pressure drops on the separation process has been analyzed. ► The overflow diameter contributed most intensely to the responses separation efficiency and flow ratio. ► The feed inlet diameter contributed most intensely to the responses capacity and C-force. ► The effect of the separation process on cell viability was evaluated and presented values below 7%.