Extraction of trans-resveratrol from red wine and optimization by response surface methodology

The optimization of liquid–liquid extraction of resveratrol from wine by organic solvent was investigated using a Doehlert design. Preliminary experiments were conducted to choose the solvent used for the experimental design. Two parameters were analysed: the composition of the binary solvent mixture and the solution/solvent ratio. The best result was obtained by superimposing the isoresponses of selectivity and yield. The optimum operating conditions for extraction were: (i) a solvent mixture of cyclohexane/pentanol with a weight ratio of 40/60 and (ii) a solution/solvent ratio of 30/70. Under these conditions, the yield is above 95% for a selectivity of about 6.6‰.

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► Cyclohexane/pentanol is the best solvent mixture for extraction of resveratrol from wine.
► The best weight ratio of cyclohexane/pentanol is 40/60 for selectivity and extraction yield.
► The best weight ratio of solution/solvent is 30/70 for selectivity and extraction yield.