کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6482101 | 386 | 2016 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer's disease
ترجمه فارسی عنوان
نانولوله های مهندسی پرتوهای یونیزه به عنوان نانوذرات انسولین برای توسعه یک استراتژی جدید برای درمان بیماری آلزایمر
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کلمات کلیدی
نانوگلد، پردازش تابش یونیزه، نانوذرات انسولین، بیماری آلزایمر، تحویل دارو هدفمند،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
A growing body of evidence shows the protective role of insulin in Alzheimer's disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer's Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility of the naked carrier is demonstrated. The insulin conjugated to the NG (NG-In) is protected by protease degradation and able to bind to insulin receptor (IR), as demonstrated by immunofluorescence measurements showing colocalization of NG-InFITC with IR. Moreover, after binding to the receptor, NG-In is able to trigger insulin signaling via AKT activation. Neuroprotection of NG-In against dysfunction induced by amyloid β (Aβ), a peptide mainly involved in AD, is verified. Finally, the potential of NG-In to be efficiently transported across the Blood Brain Barrier (BBB) is demonstrated. All together these results indicate that the synthesized NG-In is a suitable vehicle system for insulin deliver in biomedicine and a very promising tool to develop new therapies for neurodegenerative diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 80, February 2016, Pages 179-194
Journal: Biomaterials - Volume 80, February 2016, Pages 179-194
نویسندگان
Pasquale Picone, Lorena Anna Ditta, Maria Antonietta Sabatino, Valeria Militello, Pier Luigi San Biagio, Maria Laura Di Giacinto, Laura Cristaldi, Domenico Nuzzo, Clelia Dispenza, Daniela Giacomazza, Marta Di Carlo,