کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6484205 | 1416076 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-uniform viscosity caused by red blood cell aggregation may affect NO concentration in the microvasculature
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Non-uniform viscosity caused by red blood cell aggregation may affect NO concentration in the microvasculature Non-uniform viscosity caused by red blood cell aggregation may affect NO concentration in the microvasculature](/preview/png/6484205.png)
چکیده انگلیسی
Aggregation of red blood cells in the micro vasculature may affect blood viscosity in the vessel. The purpose of this study was to investigate the potential effect of non-uniform viscosity caused by red blood cell (RBC) aggregation on nitric oxide (NO) concentration and distribution. A 3-D multi-physics model was established to simulate the production, transport and consumption of NO. Two non-uniform viscosity models caused by RBC aggregation were investigated: one assuming a linear and the other a step hematocrit distribution. In addition, the effect of the thickness of the plasma layer was tested. Simulation results demonstrate that non-uniform viscosity caused by RBCs aggregation influences NO concentration distribution. Compared with the uniform viscosity model, NO concentration using non-uniform viscosity is lower than that using uniform viscosity. Moreover, NO concentration calculated from the step hematocrit model is higher than that calculated from the linear hematocrit model. NO concentrations in the endothelium and the vascular wall decrease with the decline of the thickness of the plasma layer. The relative decrease differs between the linear and the step model. Our results suggest that non-uniform viscosity caused by red blood cell aggregation affects nitric oxide distribution in the micro vasculature. If uniform viscosity is assumed when performing numerical simulations, NO concentration values may be overestimated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biocybernetics and Biomedical Engineering - Volume 37, Issue 3, 2017, Pages 341-346
Journal: Biocybernetics and Biomedical Engineering - Volume 37, Issue 3, 2017, Pages 341-346
نویسندگان
Huiting Qiao, Hongjun Zhao, Dov Jaron,