کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6484278 | 1416085 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications
ترجمه فارسی عنوان
فیلم های کوپلیمر پلی (اوره اوره) مبتنی بر آمینو اسید برای برنامه های کاربردی برای تعمیر فتق
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کلمات کلیدی
پلی اوره (اوره استر)، پلی پروپیلن، ماتریکس غیر سلولی، فتق مدول الاستیک نیروی انفجار، بافت نرم،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
The use of degradable materials is required to address current performance and functionality shortcomings from biologically-derived tissues and non-resorbable synthetic materials used for hernia mesh repair applications. Herein a series of degradable l-valine-co-l-phenylalanine poly(ester urea) (PEU) copolymers were investigated for soft-tissue repair. Poly[(1-VAL-8)0.7-co-(1-PHE-6)0.3] showed the highest uniaxial mechanical properties (332.5â¯Â±â¯3.5â¯MPa). Additionally, l-valine-co-l-phenylalanine poly(ester urea)s were blade coated on small intestine submucosa extracellular matrix (SIS-ECM) and found to enhance the burst test mechanical properties of SIS-ECM in composite films (force at break between 102.6â¯Â±â¯6.5-151.4â¯Â±â¯11.3â¯N). Free standing films of l-valine-co-l-phenylalanine PEUs were found to have superior extension at break when compared to SIS-ECM (averages between 1.2 and 1.9â¯cm and 1.2â¯cm respectively). Fibroblast (L-929) spreading, proliferation, and improved attachment over control were observed without toxicity in vitro, while a reduced inflammatory response at both 7 and 14 days post-implant was observed for poly[(1-VAL-8)â 0.7-co-(1-PHE-6)â 0.3] when compared to polypropylene in an in vivo rat hernia model. These results support the use of PEU copolymers as free-standing films or as composite materials in soft-tissue applications for hernia-repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 182, November 2018, Pages 44-57
Journal: Biomaterials - Volume 182, November 2018, Pages 44-57
نویسندگان
Nathan Z. Dreger, Zhaobo Fan, Zachary K. Zander, Chinnapatch Tantisuwanno, Molly C. Haines, Morgan Waggoner, Trenton Parsell, Claus S. Søndergaard, Michael Hiles, Christopher Premanandan, Matthew L. Becker,