Dual drug delivery and sequential release by amphiphilic Janus nanoparticles for liver cancer theranostics

A unique cage-sphere like amphiphilic PCL-AuNC/Fe(OH)3-PAA Janus nanoparticle is synthesized by a facile method, and it is designed to load hydrophobic and hydrophilic drugs in its two independent PCL-AuNC and Fe(OH)3-PAA domains, respectively, to realize the control of release order by pH and NIR stimuli, CT and MR imaging and chemo-photothermal combined cancer therapy.408