کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6484500 | 1416096 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-invasive through-skull brain vascular imaging and small tumor diagnosis based on NIR-II emissive lanthanide nanoprobes beyond 1500â¯nm
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Optical bioimaging by using the new short-wavelength infrared window (SWIR, also named as NIR-II, 1000-1700â¯nm) is emerged as a next generation imaging technique for disease diagnosis owing to the unprecedented improvements in imaging sensitivity and spatial resolution. However, it is challenging to search new imaging agents with highly biocompatible and bright narrow-band emission located in the 1500-1700â¯nm (referred as NIR-IIb) region. Here we developed high quality polyacrylic acid (PAA) modified NaYF4:Gd/Yb/Er nanorods (PAA-NRs) with remarkably enhanced NIR-IIb emission and decent bio-compatibility for in vivo cerebral vascular bioimaging and small tumor visualization. These PAA-NRs present efficient narrow-band NIR-IIb emission centered at 1520 with 182â¯nm of band-width. Owing to the highly efficient NIR-IIb emission, NIR-IIb imaging-guided small tumor (4â¯mm in diameter) detection is achieved. More importantly, non-invasive optical brain vessel bioimaging with high spatial (â¼43.65â¯Î¼m) and temporal resolution through scalp and skull is obtained without craniotomy. These findings open up the opportunity of designing non-invasive approach for visualization the brain vasculature and tumor in biomedical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 171, July 2018, Pages 153-163
Journal: Biomaterials - Volume 171, July 2018, Pages 153-163
نویسندگان
Zhenluan Xue, Songjun Zeng, Jianhua Hao,