Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin

Inspired by the ability of eukaryote to package millions of genes in the nucleus wrapping and condensing DNA around histones to form chromosomes, here we developed a karyon-like hybrid nanocarrier. By utilizing the fullerenol assembled with Dox, the polymeric nanoparticles achieved appreciable therapeutic efficiency with high encapsulation efficiency and reduced side effects.328