Photo-tearable tape close-wrapped upconversion nanocapsules for near-infrared modulated efficient siRNA delivery and therapy

A photo-tearable tape wrapped UCNP nanocapsule loaded with siRNA and photosensitizer is designed for NIR light modulated gene therapy. The high photocleavage efficiency by tape close wrapping via a synthesized photocleavable linker and ROS boosted endosomal escape of siRNA result in impressive improvement for gene therapy efficiency both in vitro and in vivo.295