کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6485014 | 379 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement
ترجمه فارسی عنوان
یک هیدروژل کامپوزیت فتو پلیمر و ابزار ایمپلنت جراحی برای جایگزینی هسته پالپوس
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کلمات کلیدی
دستگاه پزشکی، پلی اتیلن گلیکول دی متیکریلات، جراحی حداقل مهاجم، الیاف نانو سلولز، ایمپلنت ارتوپدی، عکسبرداری،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single implant or tissue replacement was able to withstand the loads within an intervertebral disc. Here, we report on the development of a photo-polymerizable poly(ethylene glycol)dimethacrylate nano-fibrillated cellulose composite hydrogel which was tuned according to native tissue properties. Using a customized minimally-invasive medical device to inject and photopolymerize the hydrogel insitu, samples were implanted through an incision of 1 mm into an intervertebral disc of a bovine organ model to evaluate their long-term performance. When implanted into the bovine disc model, the composite hydrogel implant was able to significantly re-establish disc height after surgery (p < 0.0025). The height was maintained after 0.5 million loading cycles (p < 0.025). The mechanical resistance of the novel composite hydrogel material combined with the minimally invasive implantation procedure into a bovine disc resulted in a promising functional orthopedic implant for the replacement of the nucleus pulposus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 88, May 2016, Pages 110-119
Journal: Biomaterials - Volume 88, May 2016, Pages 110-119
نویسندگان
Andreas Schmocker, Azadeh Khoushabi, Daniela A. Frauchiger, Benjamin Gantenbein, Constantin Schizas, Christophe Moser, Pierre-Etienne Bourban, Dominique P. Pioletti,