کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6485065 | 380 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Infrared-active quadruple contrast FePt nanoparticles for multiple scale molecular imaging
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A single nanomaterial with multiple imaging contrasts and functions is highly desired for multiscale theragnosis. Herein, we demonstrate single 1-1.9 μm infrared-active FePt alloy nanoparticles (FePt NPs) offering unprecedented four-contrast-in-one molecular imaging - computed tomography (CT), magnetic resonance imaging (MRI), photoacoustic (PA) imaging, and high-order multiphoton luminescence (HOMPL) microscopy. The PA response of FePt NPs outperforms that of infrared-active gold nanorods by 3- to 5.6-fold under identical excitation fluence and particle concentrations. HOMPL (680 nm) of an isolated FePt NP renders spatial full-width-at-half-maximum values of 432 nm and 300 nm beyond the optical diffraction limit for 1230-nm and 920-nm excitation, respectively. The in vivo targeting function was successfully visualized using HOMPL, PA imaging, CT, and MRI, thereby validating FePt as a single nanomaterial system covering up to four types (Optical/PA/CT/MRI) of molecular imaging contrast, ranging from the microscopic level to whole-body scale investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 85, April 2016, Pages 54-64
Journal: Biomaterials - Volume 85, April 2016, Pages 54-64
نویسندگان
Shang-Wei Chou, Chien-Liang Liu, Tzu-Ming Liu, Yu-Fang Shen, Lun-Chang Kuo, Cheng-Ham Wu, Tsung-Yuan Hsieh, Pei-Chun Wu, Ming-Rung Tsai, Che-Chang Yang, Kai-Yao Chang, Meng-Hua Lu, Pai-Chi Li, Shi-Ping Chen, Yu-Hsin Wang, Chen-Wen Lu, Yi-An Chen,