One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer

Plasmonic PEGylated MoO3-x hollow nanospheres (HNSs) with sub-100 nm were engineering designed by a facile one-pot hydrothermal process as an effective camptothecin (CPT) drug nanocarrier and a near-infrared (NIR) photothermal nanoagent for synergetic chemo-photothermal therapy based on the mesoporous structure and the high NIR phothothermal conversion efficiency. The PEG-MoO3-x HNSs has proven to be a promising candidate as a novel, single theranostic nanoagent for photoacoustic (PAT) imaging-guided chemo-photothermal therapy of cancer.245