کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6485991 | 416 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
l-Cysteine: A biocompatible, breathable and beneficial coating for graphene oxide
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
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چکیده انگلیسی
Graphene oxide (GO) has been employed in various fields, and its ecological and health risks have attracted much attention. A small and inexpensive biomolecule, l-cysteine, was covalently immobilized onto GO to form l-cysteine-GO (CysGO) as a thio-functionalized nanosheet of 1.4 nm in thickness. Both the d-spacing and crystallinity of CysGO were observed to be lower than those of GO, whereas the D and G peaks remained similar to those of GO. CysGO exhibited remarkable uptake in vivo: no tissue defects, malformation, death or significant hatching delay were observed in zebrafish embryos. Significant DNA damage, decreased Na+/K+-ATPase activity and decreased mitochondrial membrane potential were not observed for CysGO. As a nonspecific activity linked to nanotoxicology, the unpaired electron spinning intensity of CysGO was approximately two orders of magnitude lower than that of GO. Oxygen microsensor analysis showed that the hypoxic and normoxic environments resulting from the presence of GO and CysGO envelopment, respectively, contributed to the difference in biocompatibility. CysGO also protected embryos from arsenic poisoning. Thus, CysGO has the advantageous properties of GO, exhibits excellent biocompatibility, acts as a breathable coating and antidote, and is suitable for various applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 52, June 2015, Pages 301-311
Journal: Biomaterials - Volume 52, June 2015, Pages 301-311
نویسندگان
Li Mu, Yue Gao, Xiangang Hu,