Cobalt-catalyzed redox-neutral synthesis of isoquinolines: C-H activation assisted by an oxidizing N-S bond

A redox-neutral avenue to access isoquinolines has been realized by a Co(III)-catalyzed C-H activation process. Starting from readily available N-sulfinyl imine substrates and alkynes, the reaction occurred via N-S cleavage with broad substrate scope and functional group compatibility in the presence of a cost-effective cobalt catalyst.