کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6584 501 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly
چکیده انگلیسی

Non-viral gene-delivery platforms have been developed to co-deliver chemotherapeutics and siRNAs. The synergistic effects between shRNAs against survivin and Paclitaxel (PTX) using supramolecular micelles self-assembled from the host PEI-CyD (PC) composed of β-cyclodextrin (β-CyD) and polyethylenimine (PEI, Mw 600) and guest adamantine conjugated PTX (Ada-PTX) in combination cancer therapy are investigated. The Ada-PTX is encapsulated inside the core and shRNA sticks to the shell surface. The physicochemical properties of these supramolecular nanoparticles are favorable to cell uptake and intracellular trafficking. Moreover, PTX and shRNA simultaneously delivered to SKOV-3 cells lead to efficient reduction in the survivin and Bcl-2 expression as well as synergistic cell apoptotic induction in the in vitro study. In particular, co-delivery of survivin shRNA and PTX suppresses cancer growth more effectively than delivery of either paclitaxel or shRNA in ovarian cancer therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 27, September 2012, Pages 6580–6591
نویسندگان
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