Production of hyaluronic acid (HA) nanoparticles by a continuous process inside microchannels: Effects of non-solvents, organic phase flow rate, and HA concentration

▸ Higher affinities between water and the organic solvent lead to smaller particles. ▸ Higher HA concentrations lead to larger HA nanoparticles. ▸ Higher organic phase flows lead to smaller HA nanoparticles. ▸ Convection controls mass transfer inside the microchannel.