Nanoprecipitation in confined impinging jets mixers: Production, characterization and scale-up of pegylated nanospheres and nanocapsules for pharmaceutical use

► In this work nanospheres and nanocapsules for pharmaceutical applications are investigated. ► Nanoparticles are produced through solvent displacement in different micromixers. ► A preformed PEGylated derivative of cyanoacrylate is used in the experiments. ► Results show different mechanisms of formation for nanospheres and nanocapsules. ► Experiments are used to derive design and scale-up criteria.