کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6594511 | 1423668 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
One-pot four-component domino strategy for the synthesis of novel spirooxindole-pyrrolidine/pyrrolizidine-linked 1,2,3-triazole conjugates via stereo- and regioselective [3+2] cycloaddition reactions: In vitro antibacterial and antifungal studies
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, a series of highly diversified novel functionalized spirooxindolopyrrolidine and spirooxindolopyrrolizidine-linked 1,2,3-triazole conjugates have been synthesized by a one-pot, four-component condensation of (E)-2-(1-propargyl-2-oxoindoline-3-ylidene)acetophenones as bifunctional dipolarophiles, acenaphthenequinone, α-amino acids with substituted aryl azides using coinage metal catalysts. It was found that CuSO4/Na ascorbate as a catalyst was more performant than Ag2CO3 or CuI. The single-crystal X-ray analysis of one of the cycloadducts proves the structure and the regiochemistry of this reaction. The compounds have been screened for their in vitro antibacterial and antifungal activities using the agar dilution method and display good activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comptes Rendus Chimie - Volume 21, Issue 1, January 2018, Pages 41-53
Journal: Comptes Rendus Chimie - Volume 21, Issue 1, January 2018, Pages 41-53
نویسندگان
Randa Sakly, Hayet Edziri, Moheddine Askri, Michael Knorr, Carsten Strohmann, Maha Mastouri,