کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6597336 1423852 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Data on crystal organization in the structure of the Fab fragment from the NIST reference antibody, RM 8671
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Data on crystal organization in the structure of the Fab fragment from the NIST reference antibody, RM 8671
چکیده انگلیسی
The reported data describe the crystallization, crystal packing, structure determination and twinning of the unliganded Fab (antigen-binding fragment) from the NISTmAb (standard reference material 8671). The raw atomic coordinates are available as Protein Data Bank structure 5K8A and biological aspects are described in the article, (Karageorgos et al., 2017) [1]. Crystal data show that the packing is unique, and show the basis for the crystal's twinned growth. Twinning is a common and often serious problem in protein structure determination by x-ray crystallography [2]. In the present case the twinning is due to a small deviation (about 0.3 nm) from 4-fold symmetry in the primary intermolecular interface. The deviation produces pseudosymmetry, generating slightly different conformations of the protein, and alternating strong and weak forms of key packing interfaces throughout the lattice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Data in Brief - Volume 16, February 2018, Pages 29-36
نویسندگان
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