Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique

- Supercritical assisted atomization was used for the nano-encapsulation of rifampicin.
- Mean particle diameter was between 123 and 148 nm.
- Encapsulation efficiencies greater than 100% was achieved.
- Sustained rifampicin release over a 17-day period following initial burst release.