Kinetic resolution of 4-phenyl-2-azetidinone in supercritical carbon dioxide

▶ Kinetic resolution of rac-4-phenyl-2-azetidinone in supercritical carbon dioxide. ▶ Enantioselectivity higher than 100, full conversion of the substrate. ▶ Optimal pressure (14 MPa) and optimal temperature (70 °C) determined. ▶ Green separation of the substrate and product from each other and from the enzyme.