Overexpression of native PSE1 and SOD1 in Saccharomyces cerevisiae improved heterologous cellulase secretion

► Enzyme production in Saccharomyces cerevisiae can be greatly improved by overexpressing native genes. ► Overproduction SOD1 and PSE1 can increase cellulase production more than threefold. ► This paves the way for more efficient enzyme production by cellulolytic yeast. ► This may be imperative to creating optimal strains for consolidated bioprocessing.