کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
675516 1459625 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Compatibility studies of lapachol with pharmaceutical excipients for the development of topical formulations
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Compatibility studies of lapachol with pharmaceutical excipients for the development of topical formulations
چکیده انگلیسی

Among naphthoquinones, lapachol and many heterocyclic derivatives have been investigated during the past years, mainly due to their antibacterial, antifungal and anticancer activities. Assessment of possible incompatibility between an active component (i.e. lapachol) and different excipients along with the evaluation of thermal stability are crucial parts of a normal study prior to the final formulation setting of a medicine. DSC study was used as an important and complementary tool during pre-formulation to determine the compatibility of drug-excipients with the purpose of developing a lapachol gel-cream formulation. The DSC curves of lapachol (Lpch) and binary mixtures with excipients (propylparaben, methylparaben, edetic acid, isodecyl oleate, trietanolamine, glyceril monoesterate, cetiol, glicerin, carbopol, cetomacrogol and mineral oil) were obtained. The results showed that Lpch only exhibited interaction which could influence the stability of the product in the binary mixtures of Lpch/methylparaben, Lpch/cetostearyl alcohol and Lpch/glyceryl monostearate. There was a significant shift or absence of lapachol melting peak in both cases. Photovisual DSC was used to confirm the results obtained with conventional DSC because it is a more sensitive method.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thermochimica Acta - Volume 457, Issues 1–2, 15 June 2007, Pages 1–6
نویسندگان
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