کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6799841 | 862791 | 2016 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of SLC25A37 as a major depressive disorder risk gene
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
Major depressive disorder (MDD) is one of the most prevalent and disabling mental disorders, but the genetic etiology remains largely unknown. We performed a meta-analysis (14,543 MDD cases and 14,856 controls) through combining the GWAS data from the Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and the CONVERGE consortium and identified seven SNPs (four of them located in the downstream of SCL25A37) that showed suggestive associations (PÂ <Â 5.0Â ÃÂ 10â7) with MDD. Systematic integration (Sherlock integrative analysis) of brain eQTL and GWAS meta-analysis identified SCL25A37 as a novel MDD risk gene (PÂ =Â 2.22Â ÃÂ 10â6). A cis SNP (rs6983724, â¼28Â kb downstream of SCL25A37) showed significant association with SCL25A37 expression (PÂ =Â 1.19Â ÃÂ 10â9) and suggestive association with MDD (PÂ =Â 1.65Â ÃÂ 10â7). We validated the significant association between rs6983724 and SCL25A37 expression in independent expression datasets. Finally, we found that SCL25A37 is significantly down-regulated in hippocampus and blood of MDD patients (PÂ =Â 3.49Â ÃÂ 10â3 and PÂ =Â 2.66Â ÃÂ 10â13, respectively). Our findings implicate that the SCL25A37 is a MDD susceptibility gene whose expression may influence MDD risk. The consistent down-regulation of SCL25A37 in MDD patients in three independent samples suggest that SCL25A37 may be used as a potential biomarker for MDD diagnosis. Further functional characterization of SCL25A37 may provide a potential target for future therapeutics and diagnostics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 83, December 2016, Pages 168-175
Journal: Journal of Psychiatric Research - Volume 83, December 2016, Pages 168-175
نویسندگان
Yong-Xia Huo, Liang Huang, Deng-Feng Zhang, Yong-Gang Yao, Yi-Ru Fang, Chen Zhang, Xiong-Jian Luo,