کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6800925 | 542443 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fiber tract associated with autistic traits in healthy adults
ترجمه فارسی عنوان
دستگاه فیبر همراه با ویژگی های اوتیستیک در بزرگسالان سالم است
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کلمات کلیدی
اوتیسم، آمار فضایی مبتنی بر تراکت، تراکتوری، سوزن طولانی پشتی پشتی، فسیکولوس پیشانی-اوسیپیتال پایین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with impairment of social communication and restricted and repetitive behaviors. Reduced fractional anisotropy (FA), a measure of white matter integrity, in the posterior superior temporal sulcus (pSTS) is related to ASD. However, there are several major fibers in pSTS, and it is unknown which of them is associated with ASD. We investigated FA in correlation with autistic traits assessed by autism spectrum quotient (AQ) in 91 healthy adults using tract-based spatial statistics (TBSS). Then, of the fibers in pSTS, we identified the one in which FA was linked to the AQ score using tractography. TBSS revealed that AQ was correlated with FA of white matter in several regions such as the frontal lobe, parietal lobe, occipital lobe and temporal lobe including pSTS. With further analysis using tractography, we confirmed that FA alteration in pSTS was located on the inferior fronto-occipital fasciculus (IFOF). IFOF has a critical role in processing socio-emotional information. Our findings suggest that of the fibers in pSTS, IFOF is a key fiber that links to autistic traits in healthy adults.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 59, December 2014, Pages 117-124
Journal: Journal of Psychiatric Research - Volume 59, December 2014, Pages 117-124
نویسندگان
Kimito Hirose, Jun Miyata, Genichi Sugihara, Manabu Kubota, Akihiko Sasamoto, Toshihiko Aso, Hidenao Fukuyama, Toshiya Murai, Hidehiko Takahashi,