کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6802846 | 1433516 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perfusion alterations converge with patterns of pathological spread in transactive response DNA-binding protein 43 proteinopathies
ترجمه فارسی عنوان
تغییرات افسردگی با الگوهای گسترش پاتولوژیک در پروتئین آپاتیک پروتئین پروتئینی مرتبط با پروتئین پروتئینی مرتبط با پروتئین پروتئینی همگرا است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Amyotrophic lateral sclerosis (ALS) and the behavioral variant of frontotemporal dementia (bvFTD) commonly share the presence of transactive response DNA-binding protein 43 (TDP-43) inclusions. Structural magnetic resonance imaging studies demonstrated evidence for TDP-43 pathology spread, but while structural imaging usually reveals overt neuronal loss, perfusion imaging may detect more subtle neural activity alterations. We evaluated perfusion as an early marker for incipient pathology-associated brain alterations in TDP-43 proteinopathies. Cortical thickness (CT) and perfusion measurements were obtained in ALS (NÂ = 18), pathologically and/or genetically confirmed bvFTD-TDP (NÂ = 12), and healthy controls (NÂ = 33). bvFTD showed reduced frontotemporal CT, hypoperfusion encompassing orbitofrontal and temporal cortices, and hyperperfusion in motor and occipital regions. ALS did not show reduced CT, but exhibited hypoperfusion in motor and temporal regions, and hyperperfusion in frontal and occipital cortices. Frontotemporal hypoperfusion and reduced CT correlated with cognitive and behavioral impairments as investigated using Mini-Mental State Examination and Philadelphia Brief Assessment of Cognition in bvFTD, and hypoperfusion in motor regions correlated with motor disability as measured by the ALS Functional Rating Scale-Revised in ALS. Hypoperfusion marked early pathologically involved regions, while hyperperfusion characterized regions of late pathological involvement. Distinct perfusion patterns may provide early markers of pathology distribution in TDP-43 proteinopathies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 68, August 2018, Pages 85-92
Journal: Neurobiology of Aging - Volume 68, August 2018, Pages 85-92
نویسندگان
Pilar M. Ferraro, Charles Jester, Christopher A. Olm, Katerina Placek, Federica Agosta, Lauren Elman, Leo McCluskey, David J. Irwin, John A. Detre, Massimo Filippi, Murray Grossman, Corey T. McMillan,