کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6802899 1433517 2018 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study
ترجمه فارسی عنوان
از دست دادن دندان با کاهش شکاف شناختی و اختلاف مغناطیسی مغز مرتبط است: یک مطالعه مبتنی بر جمعیت
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Tooth loss has been related to cognitive impairment; however, its relation to structural brain differences in humans is unknown. Dementia-free participants (n = 2715) of age ≥60 years were followed up for up to 9 years. A subsample (n = 394) underwent magnetic resonance imaging at baseline. Information on tooth loss was collected at baseline, and cognitive function was assessed using the Mini-Mental State Examination at baseline and at follow-ups. Data were analyzed using linear mixed effects models and linear regression models. At baseline, 404 (14.9%) participants had partial tooth loss, and 206 (7.6%) had complete tooth loss. Tooth loss was significantly associated with a steeper cognitive decline (β: −0.18, 95% confidence interval [CI]: −0.24 to −0.11) and remained significant after adjusting for or stratifying by potential confounders. In cross-sectional analyses, persons with complete or partial tooth loss had significantly lower total brain volume (β: −28.89, 95% CI: −49.33 to −8.45) and gray matter volume (β: −22.60, 95% CI: −38.26 to −6.94). Thus, tooth loss may be a risk factor for accelerated cognitive aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 67, July 2018, Pages 23-30
نویسندگان
, , , , , , , ,